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A Reappraisal of Oral Quinine in Discoid Lupus Erythematosus *
Author(s) -
Nuse David S.
Publication year - 1972
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1972.tb00486.x
Subject(s) - medicine , quinine , nausea , drug , discoid lupus erythematosus , dermatology , systemic lupus erythematosus , lupus erythematosus , surgery , pharmacology , malaria , disease , pathology , immunology , antibody
SUMMARY Quinine is described as one of the treatments used for discoid lupus erythaematosus in older text books but this drug has been supplanted in the last 25 years by synthetic antlmalarials. A trial of quinine bisulphate in eleven patients with this condition has been made, for periods up to two years. Half the patients showed improvement, in one case after failure to respond to other standard methods of treatment. Two patients could not take the drug because of nausea, and others showed no effect, or have been lost to follow‐up. As the side effects of quinine can be severe, this drug should be reserved for use when more conventional treatment is ineffective or is contraindicated.