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Gestagen Treatment of Scleroderma
Author(s) -
Holzmakn H.,
Kortisg G. W.,
Mobsches B.
Publication year - 1968
Publication title -
australasian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.67
H-Index - 53
eISSN - 1440-0960
pISSN - 0004-8380
DOI - 10.1111/j.1440-0960.1968.tb01611.x
Subject(s) - medicine , scleroderma (fungus) , hydroxyproline , connective tissue , connective tissue disease , disease , pathology , dermatology , autoimmune disease , inoculation
SUMMARY In accordance with the biochemical conditions of collagen metabolism in progressive scleroderma and an account of previous experimental investigations of different therapeutic agents in the connective tissue, of animals, we. studied the pathogenetic treatment of this disease with gestagens and give, a detailed report of our own experimental research, in animals and the experience, obtained in patients. Evidence has been presented that an increase of the urinary excretion of hydroxyproline in patients with, progressive, scleroderma is an essential effect of the. progesterone therapy.