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Why is it so Difficult to Derive Pluripotent Stem Cells in Domestic Ungulates?
Author(s) -
Gandolfi F,
Pennarossa G,
Maffei S,
Brevini TAL
Publication year - 2012
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/j.1439-0531.2012.02106.x
Subject(s) - induced pluripotent stem cell , biology , stem cell , human induced pluripotent stem cells , neuroscience , evolutionary biology , microbiology and biotechnology , embryonic stem cell , genetics , gene
Content Pluripotent stem cells are the focus of an extremely active field of investigation that is bringing new light on our understanding of the mechanisms that control pluripotency and differentiation. Rodent and primates are the only species where true, or bona fide , pluripotent stem cells have been derived. The attempts to derive pluripotent stem cells from domestic ungulates have been going on for more than 20 years with little progress. Cell lines from these species present a series of limitations that have precluded their use for both basic and clinically oriented studies. However, in the last 3 years, some substantial progress have been made making the currently available ungulate pluripotent stem cells closest than ever before to their human and mouse counterpart. This result has been achieved through both conceptual and technical progress that will be illustrated and discussed in this review.