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Advancing Pig Cloning Technologies Towards Application in Regenerative Medicine
Author(s) -
Nagashima H,
Matsunari H,
Nakano K,
Watanabe M,
Umeyama K,
Nagaya M
Publication year - 2012
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/j.1439-0531.2012.02065.x
Subject(s) - regenerative medicine , cloning (programming) , basic research , translational medicine , biology , computational biology , microbiology and biotechnology , engineering ethics , bioinformatics , computer science , stem cell , genetics , engineering , library science , programming language
Contents Regenerative medicine is expected to make a significant contribution by development of novel therapeutic treatments for intractable diseases and for improving the quality of life of patients. Many advances in regenerative medicine, including basic and translational research, have been developed and tested in experimental animals; pigs have played an important role in various aspects of this work. The value of pigs as a model species is being enhanced by the generation of specially designed animals through cloning and genetic modifications, enabling more sophisticated research to be performed and thus accelerating the clinical application of regenerative medicine. This article reviews the significant aspects of the creation and application of cloned and genetically modified pigs in regenerative medicine research and considers the possible future directions of the technology. We also discuss the importance of reproductive biology as an interface between basic science and clinical medicine.