Premium
MHC Class II is an Important Genetic Risk Factor for Canine Systemic Lupus Erythematosus (SLE)‐Related Disease: Implications for Reproductive Success
Author(s) -
Wilbe M,
Andersson G
Publication year - 2012
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/j.1439-0531.2011.01962.x
Subject(s) - major histocompatibility complex , immunology , biology , disease , genotype , haplotype , systemic lupus erythematosus , canis , immune system , genetics , risk factor , gene , medicine , paleontology
Contents Major histocompatibility complex (MHC) class II genes are important genetic risk factors for development of immune‐mediated diseases in mammals. Recently, the dog ( Canis lupus familiaris ) has emerged as a useful model organism to identify critical MHC class II genotypes that contribute to development of these diseases. Therefore, a study aimed to evaluate a potential genetic association between the dog leukocyte antigen (DLA) class II region and an immune‐mediated disease complex in dogs of the Nova Scotia duck tolling retriever breed was performed. We show that DLA is one of several genetic risk factors for this disease complex and that homozygosity of the risk haplotype is disadvantageous. Importantly, the disease is complex and has many genetic risk factors and therefore we cannot provide recommendations for breeders exclusively on the basis of genetic testing for DLA class II genotype.