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Morphological Examination of the Corpora Lutea from Pregnant Bitches Treated with Different Abortifacient Regimes
Author(s) -
Martin N,
Höftmann T,
Politt E,
Hoppen HO,
Sohr M,
GünzelApel AR,
Einspanier A
Publication year - 2009
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/j.1439-0531.2009.01430.x
Subject(s) - corpus luteum , luteolysis , relaxin , luteal phase , endocrinology , medicine , abortifacient , agonist , cabergoline , receptor , prostaglandin , biology , pregnancy , chemistry , hormone , mifepristone , prolactin , genetics
Contents Different abortifacient regimes in dogs were analysed for their effect on the pregnancy corpora lutea (CL), namely, prostaglandin F2a analogue cloprostenol (CLO) combined with dopamine agonist cabergoline (CAB), or progesterone (P4) receptor antagonist aglepristone (AGL). Ovaries were collected after 6‐10 days of treatment during first trimester. The CL of the control‐group showed strong expression of relaxin (RLX), its receptor RXFP1 and enzymes of steroid biosynthesis (HSD) with high peripheral P4‐levels. Whereas RXL, RXFP1 and HSD were lowest expressed in the CLO/CAB‐group with a massive degeneration of CL and their blood vessels combined with low peripheral P4‐level. The AGL‐group showed less extensive CL degeneration and more intensive staining of the examined factors than CLO/CAB. In summary, all examined factors are associated with normal luteal function and are useful tools to stage luteolysis. Although both treatments have the same abortive action, their sequence of events on the CL is different.