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Regulation of the Spermatogonial Stem Cell Niche
Author(s) -
Kostereva N,
Hofmann MC
Publication year - 2008
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/j.1439-0531.2008.01189.x
Subject(s) - niche , biology , microbiology and biotechnology , stem cell niche , stem cell , sertoli cell , ecological niche , cell , ecology , genetics , spermatogenesis , progenitor cell , endocrinology , habitat
Contents Spermatogonial stem cells (SSCs) reside within specialized microenvironments called ‘niches’, which are essential for their maintenance and self‐renewal. In the mammalian testis, the main components of the niche include the Sertoli cell, the growth factors that this nursing cell produces, the basement membrane, and stimuli from the vascular network between the seminiferous tubules. This review focuses on signalling pathways maintaining SSCs self‐renewal and differentiation and describes potential mechanisms of regulation of the spermatogonial stem cell niche.