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Immunohistochemistry Diagnosis of an Ovarian Dysgerminoma in One Bitch
Author(s) -
Park JK,
Goo MJ,
Hong IH,
Ki MR,
Han JY,
Jeong KS
Publication year - 2009
Publication title -
reproduction in domestic animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.546
H-Index - 66
eISSN - 1439-0531
pISSN - 0936-6768
DOI - 10.1111/j.1439-0531.2008.01135.x
Subject(s) - dysgerminoma , cytokeratin , pathology , vimentin , placental alkaline phosphatase , immunohistochemistry , neoplasm , ovary , alkaline phosphatase , biology , medicine , endocrinology , biochemistry , enzyme
Contents An ovarian enlargement (diameter, 8 cm) was identified and surgically excised from a 5‐year‐old female dog. Microscopic examination of the multinodular neoplasm revealed sheets of polygonal neoplastic cells with large nuclei, frequent mitosis, necrosis and haemorrhage. Immunohistochemically, the neoplastic cells were positive for vimentin and alkaline phosphatase but were negative for CD3, CD79a, cytokeratin, alpha‐fetoprotein, inhibin‐α and S‐100. The histopathological diagnosis of the mass was unilateral ovarian dysgerminoma.