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Revival of a well‐known, but ignored correction term for χ 2 in linkage analysis with small samples
Author(s) -
HÜHN M.
Publication year - 1998
Publication title -
plant breeding
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.583
H-Index - 71
eISSN - 1439-0523
pISSN - 0179-9541
DOI - 10.1111/j.1439-0523.1998.tb01456.x
Subject(s) - linkage (software) , term (time) , multinomial distribution , statistics , genetic linkage , biology , statistical physics , mathematics , econometrics , algorithm , genetics , physics , quantum mechanics , gene
The ‘classical’χ 2 test is routinely applied in linkage analysis. The values customarily used, however, are only approximations since continuous χ 2 terms are used instead of discrete multinomial terms. This error becomes increasingly important as the sample becomes small. In this note, a well‐known correction term for improvement of this approximation is revived and numerically calculated for some interesting cases from linkage studies.