Premium
Successful treatment of disseminated fusariosis with voriconazole in an acute lymphoblastic leukaemia patient
Author(s) -
Labois Aurelie,
Gray Christian,
Lepretre Stephane
Publication year - 2011
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2011.02136.x
Subject(s) - fusariosis , caspofungin , voriconazole , medicine , neutropenia , chemotherapy , dermatology , amphotericin b , immunology , antifungal , fusarium , biology , horticulture
Summary Fusarium species are actually the second most common pathogenic mould in immunocompromised patients, and it is difficult to treat such fusarial infections with current antifungal agents. We report the case of a 53‐year‐old woman with Philadelphia‐positive acute lymphoblastic leukaemia. During induction chemotherapy with febrile neutropenia, she developed a disseminated fusariosis, with persistent fever refractory to antibacterial agents and caspofungin (as empirical therapy), painful skin lesions and respiratory impairment. Fusarium solani was isolated from skin biopsy. Voriconazole was successfully implemented as antifungal curative therapy. During the second intensive chemotherapy no reactivation of fusariosis was detected.