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Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran
Author(s) -
Szigeti Gyöngyi,
Sedaghati Ebrahim,
Mahmoudabadi Ali Zarei,
Naseri Ali,
Kocsubé Sándor,
Vágvölgyi Csaba,
Varga János
Publication year - 2012
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2011.02103.x
Subject(s) - itraconazole , terbinafine , fluconazole , ketoconazole , aspergillus , microbiology and biotechnology , amphotericin b , aspergillus awamori , aspergillus niger , biology , aspergillosis , antifungal , botany , food science , fermentation
Summary Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited moderate susceptibilities against amphotericin B, fluconazole and ketoconazole. Aspergillus niger and A. awamori were found to have higher minimal inhibitory concentrations for azoles than A. tubingensis , in accordance with previous findings.

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