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Inhibitory effect of sodium hypochlorite and chlorhexidine digluconate in clinical isolates of Sporothrix schenckii
Author(s) -
Madrid Isabel Martins,
Mattei Antonella Souza,
Santin Rosema,
dos Reis Gomes Angelita,
Cleff Marlete Brum,
Meireles Mário Carlos Araújo
Publication year - 2012
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2011.02101.x
Subject(s) - sodium hypochlorite , sporotrichosis , sporothrix , chlorhexidine , microbiology and biotechnology , sporothrix schenckii , agar , chemistry , minimum inhibitory concentration , antimicrobial , medicine , dentistry , biology , bacteria , pathology , genetics , organic chemistry
Summary The susceptibility of Sporothrix schenckii isolates from clinical cases of canine, feline and human sporotrichosis, and from the environment, was evaluated with 4% sodium hypochlorite and 6.6% chlorhexidine digluconate using the broth microdilution, agar diffusion and direct exposure techniques. The minimal inhibitory concentration was smaller than 0.8% for chlorhexidine digluconate and between 8% and 4% for sodium hypochlorite. Inhibition zones were not found in agar diffusion for sodium hypochlorite, and zones averaging 1.9 mm were found for chlorhexidine digluconate. In the direct exposure test, sodium hypochlorite demonstrated best performance at 20 min of contact, as chlorhexidine digluconate presented little antimicrobial activity.