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Aloe vera extract reduces both growth and germ tube formation by Candida albicans
Author(s) -
Bernardes Ivy,
Felipe Rodrigues Monalisa Poliana,
Bacelli Gabrielle Klug,
Munin Egberto,
Alves Leandro Procópio,
Costa Maricilia Silva
Publication year - 2012
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2011.02079.x
Subject(s) - aloe vera , germ tube , candida albicans , corpus albicans , microbiology and biotechnology , biology , germ , virulence , chemistry , biochemistry , gene
Summary Due to the increased number of immunocompromised patients, the infections associated with the pathogen of the genus Candida have significantly increased in recent years. To grow, Candida albicans may form a germ tube extension from the cells, which is essential for virulence. In this work, we studied the effect of crude glycolic extract of Aloe vera fresh leaves (20% w/v) on growth and germ tube formation by C. albicans . The C. albicans growth was determined in the presence of different concentrations of A. vera extracts in Sabouraud dextrose broth medium. In the presence of A. vera extract (10% v/v), the pronounced inhibition in the C. albicans growth (90–100%) was observed. This inhibition occurred parallel to the decrease in the germ tube formation induced by goat serum. Our results demonstrated that A. vera fresh leaves plant extract can inhibit both the growth and the germ tube formation by C. albicans . Our results suggest the possibility that A. vera extract may be used as a promising novel antifungal treatment.