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Meningitis caused by Filobasidium uniguttulatum : case report and overview of the literature
Author(s) -
Pan Weihua,
Liao Wanqing,
Hagen Ferry,
Theelen Bart,
Shi Weimin,
Meis Jacques F.,
Boekhout Teun
Publication year - 2012
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2011.02054.x
Subject(s) - cryptococcus neoformans , cryptococcus gattii , cryptococcus , cryptococcosis , flucytosine , meningitis , antifungal , biology , fluconazole , cryptococcal meningitis , microbiology and biotechnology , medicine , immunology , human immunodeficiency virus (hiv) , viral disease , pediatrics
Summary Cryptococcal meningitis is mainly caused by Cryptococcus neoformans and Cryptococcus gattii , but occasionally other Cryptococcus species and phylogenetically related species are involved. Herein, we present a case of cryptococcal meningitis from China, which was caused by an azole and flucytosine resistant Filobasidium uniguttulatum . In addition, we present an overview of the literature of meningitis caused by Cryptococcus species other than C. neoformans and C. gattii . Eight cases were related to infections of the central nervous system. Leukaemia and cancer were important risk factors in HIV‐negative patients. Molecular identification and susceptibility testing are important for proper management of patients because the species involved may differ in susceptibility to antifungal drugs.