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A morphogenetic regulatory role for ethyl alcohol in Candida albicans
Author(s) -
Chauhan Nitin M.,
Raut Jayant S.,
Karuppayil S. Mohan
Publication year - 2011
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2010.02002.x
Subject(s) - germ tube , farnesol , candida albicans , alcohol , ethanol , morphogenesis , ethyl cellulose , chemistry , microbiology and biotechnology , acetaldehyde , biology , biochemistry , organic chemistry , gene , polymer
Summary Regulation of morphogenesis through the production of chemical signalling molecules such as isoamyl alcohol, 2‐phenylethyl alcohol, 1‐dodecanol, E ‐nerolidol and farnesol is reported in Candida albicans . The present study focuses on the effect of ethyl alcohol on C. albicans dimorphism and biofilm development. Ethyl alcohol inhibited germ tube formation induced by the four standard inducers in a concentration‐dependent manner. The germ tube inhibitory concentration (4%) did not have any effect on the growth and viability of C. albicans cells. Ethyl alcohol also inhibited the elongation of germ tubes. Four percentage of ethyl alcohol significantly inhibited biofilm development on polystyrene and silicone surfaces. We suggest a potential morphogenetic regulatory role for ethyl alcohol, which may influence dissemination, virulence and establishment of infection.