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In vitro antifungal evaluation and structure–activity relationship of diphenyl diselenide and synthetic analogues
Author(s) -
Loreto Érico Silva,
Nunes Mario Débora Alves,
Santurio Janio Morais,
Alves Sydney Hartz,
Nogueira Cristina Wayne,
Zeni Gilzon
Publication year - 2011
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2010.01994.x
Subject(s) - diphenyl diselenide , candida albicans , chemistry , in vitro , fungicide , antifungal , stereochemistry , fusarium , minimum inhibitory concentration , candida dubliniensis , corpus albicans , microbiology and biotechnology , selenium , biology , biochemistry , botany , organic chemistry
Summary We report on in vitro antifungal activity and the structure–activity relationship of diphenyl diselenide [(PhSe) 2 ] and its synthetic analogues, ( p ‐Cl‐C 6 H 4 Se) 2 , ( m ‐CF 3 ‐C 6 H 4 Se) 2 and ( p ‐CH 3 O‐C 6 H 4 Se) 2 , against 116 strains of pathogenic fungi. (PhSe) 2 showed the highest inhibitory activity against Candida albicans (minimum inhibitory concentration of 4–32 μg ml −1 ), Candida dubliniensis (2–16 μg ml −1 ), Aspergillus spp. (0.5–64 μg ml −1 ) and Fusarium spp. (2–16 μg ml −1 ). Its minimum fungicidal concentration (MFC) varied among C. albicans (4–64 μg ml −1 ), C. dubliniensis (2–32 μg ml −1 ) and Fusarium spp. (4–64 μg ml −1 ). Antifungal activity was decreased by the introduction of functional groups to the (PhSe) 2 molecule: (PhSe) 2 > ( p ‐CH 3 O‐C 6 H 4 Se) 2 > ( m ‐CF 3 ‐C 6 H 4 Se) 2 > ( p ‐Cl‐C 6 H 4 Se) 2 .