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Therapeutic efficacy of topical OLEOZON ® in patients suffering from onychomycosis
Author(s) -
Menéndez Silvia,
Falcón Leopoldina,
Maqueira Yordana
Publication year - 2011
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2010.01898.x
Subject(s) - ketoconazole , medicine , antifungal , dermatology , surgery , sunflower oil , therapeutic effect , mycosis , pathology
Summary The results of the use of ozonised sunflower oil (OLEOZON ® ) in the treatment of onychomycosis, based on its known antimycotic action and good skin tolerance, by means of a controlled randomised phase III assay are presented. A total of 400 outpatients were randomly divided into two groups: experimental, treated with topical OLEOZON ® , two times per day and control, treated also two times per day, with ketoconazole cream 2%, for 3 months. A patient was considered cured when the sick nails regained the normal colour, growth and thickness, with a negative mycological study. In the experimental group, a regression of signs was achieved from the first month of treatment, while in the control group, it was obtained after the third month of treatment. All patients treated with OLEOZON ® had improvement in their condition (9.5%) or were cured (90.5%). However, in the control group, only 13.5% of patients were cured, 27.5% improved and 59% remained the same, with significant differences between both the groups. After 1 year of follow‐up, experimental and control groups presented 2.8% and 44.4% of relapses, respectively. Topical OLEOZON ® demonstrated effectiveness in the treatment of onychomycosis, superior to that of ketoconazole. No side effects were observed.