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Phaeohyphomycosis of the face caused by Exophiala oligosperma
Author(s) -
Tokuhisa Yumie,
Hagiya Yumiko,
Hiruma Masataro,
Nishimura Kazuko
Publication year - 2011
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2009.01845.x
Subject(s) - giant cell , phaeohyphomycosis , biology , pathology , hypha , histopathology , multinucleate , periodic acid–schiff stain , mycosis , staining , internal transcribed spacer , anatomy , microbiology and biotechnology , ribosomal rna , botany , gene , medicine , biochemistry , immunology
Summary A 57‐year‐old previously healthy woman who works in the fish‐processing industry presented with a 1‐year history of a slightly pruritic, hyperkeratotic, brownish, erythematous lesion of the left cheek measuring 5 × 5 mm in diameter. Histopathology revealed granuloma formation in the superficial dermal layer by multinucleated giant cells that contained pale‐brown septate hyphae. Periodic acid‐Schiff stain showed many hyphae and catenate spores within the multinucleated giant cells. Tissue specimens and skin scrapings were obtained and incubated on mycosel agar, yielding black, velvety colonies that were morphologically identified as belonging to Exophiala species. Sequence analysis of the internal transcribed spacer region of the ribosomal RNA gene showed 99–100% homology to Exophiala oligosperma sequences. This report describes a rare case of phaeohyphomycosis of the face caused by E. oligosperma .