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Successful management of invasive aspergillosis presenting as pericarditis in an adult patient with chronic granulomatous disease
Author(s) -
Mortensen Klaus L.,
Knudsen Jane B.,
JensenFangel Søren,
StausbølGrøn Brian,
Arendrup Maiken C.,
Petersen Eskild
Publication year - 2011
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2009.01835.x
Subject(s) - chronic granulomatous disease , medicine , aspergillosis , pericarditis , galactomannan , antifungal , disease , differential diagnosis , intensive care medicine , dermatology , immunology , surgery , pathology
Summary Invasive aspergillosis (IA) is a major cause of death among patients with chronic granulomatous disease (CGD). Few cases of cardiac aspergillosis have been published on CGD patients. Diagnosis of IA in CGD patients can be hampered by lack of characteristic symptoms and clinical signs and the serum galactomannan assay is often negative. We report the first CGD patient with IA presenting as pericarditis where combined antifungal therapy resulted in a successful outcome.