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Rhinofacial conidiobolomycosis caused by Conidiobolus coronatus in a Chinese rice farmer
Author(s) -
Yang Xiumin,
Li Yadi,
Zhou Xiaoqian,
Wang Yuxin,
Geng Suying,
Liu Honggang,
Yang Qingwen,
Lu Xinxin,
Hiruma Masataro,
Sugita Takashi,
Ikeda Shigaku,
Ogawa Hideoki
Publication year - 2010
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2009.01716.x
Subject(s) - conidium , histopathology , itraconazole , eosinophilic , biology , hypha , pathology , medicine , microbiology and biotechnology , botany , antifungal
Summary We provide the first report of rhinofacial conidiobolomycosis caused by Conidiobolus coronatus in China. The patient was a 36‐year‐old male rice farmer from Jiang Xi province who presented with diffuse swelling with classical centrofacial distribution and involvement of the right paranasal sinuses. Histopathology showed granulomas with hyphae surrounded by an eosinophilic sheath (Splendore–Hoeppli phenomenon). Culture of biopsy specimens on Sabouraud’s dextrose agar led to the growth of fungi with microscopically visible conidiophores and terminal spherical conidia (primary conidium), with multiple secondary conidia and villose conidia. The patient was successfully treated with combination therapy, primarily itraconazole and terbinafine. We conclude with a brief literature review of the epidemiology of conidiobolomycosis.