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Chronic oral ulcer associated with Candida
Author(s) -
Terai Haruhiko,
Shimahara Masashi
Publication year - 2010
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2008.01675.x
Subject(s) - medicine , miconazole , stomatitis , recurrent aphthous stomatitis , direct examination , lesion , mycosis , gastroenterology , candida albicans , histopathological examination , pathology , dermatology , surgery , antifungal , biology , political science , law , genetics
Summary In the patients with HIV infection, fungal diseases may cause ulceration in the oral cavity; however, there have been few studies on oral ulcerative lesions associated with Candida in the patients without HIV infection. Our study included six patients with chronic oral ulcer of unknown origin; these patients were referred to our department after topical steroid therapy to the lesion was ineffective. Cases of traumatic ulcers and recurrent aphthous stomatitis were excluded. Blood, histopathological, culture and direct cytological examinations were performed. All the patients were treated with topical miconazole gel . Histopathological examination revealed no specific findings besides inflammatory cellular infiltration with positive haematoxylin–eosin staining in all cases. Candida spp. were isolated in four cases by culture test, and fungal pseudohyphae were revealed in four cases by direct examination. The anti‐fungal treatment produced a satisfactory outcome with complete remission in five cases and remarkable response in one case. These results suggested that Candida should be considered as playing an important role in a certain oral ulcer.