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Candida infection in HIV positive patients 1985–2007
Author(s) -
Traeder Christian,
Kowoll Susann,
Arastéh Keikawus
Publication year - 2008
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2008.01574.x
Subject(s) - incidence (geometry) , fluconazole , candida albicans , medicine , human immunodeficiency virus (hiv) , cohort , candida infections , esophageal candidiasis , aids related opportunistic infections , immunology , antifungal , microbiology and biotechnology , biology , sida , dermatology , viral disease , optics , physics
Summary Infection with Candida species remains a major problem in HIV infected patients. The analysis of over 15000 hospitalisations (1985–2007) in the AVK cohort shows an increasing incidence of non‐ albicans species in candida esophagitis. Although our analysis shows a decreasing incidence of opportunistic infections like PCP, cerebral toxoplasmosis and others since the introduction of highly active antiretroviral therapy the incidence of candida esophagitis remains as high as in the years before the HAART era. This observation might reflect the development of resistance against fluconazole and the selection of non‐ albicans species as a consequence of a long‐term prophylactic treatment of HIV+ patients over years.