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Potent anti‐microbial activity of traditional Chinese medicine herbs against Candida species
Author(s) -
Seneviratne C. Jayampath,
Wong Ricky W. K.,
Samaranayake Lakshman P.
Publication year - 2008
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2007.01431.x
Subject(s) - candida krusei , candida glabrata , candida tropicalis , candida albicans , candida dubliniensis , broth microdilution , traditional medicine , microbiology and biotechnology , minimum inhibitory concentration , antifungal , biology , corpus albicans , chemistry , medicine , antimicrobial
Summary Anti‐candidial activities of eight traditional Chinese medicinal (TCM) herbs were evaluated against six different Candida species. TCM preparations were screened for antifungal activity using a standard agar diffusion assay. Following identification of potential candidate herbs, their minimum inhibitory concentration (MIC) values were determined using the standardised NCCLS M‐27A broth microdilution assay. Among TCM herbs, Rhizoma Coptidis had potent antifungal activity against Candida glabrata , Candida krusei and Candida tropicalis , but not against Candida albicans , Candida dubliniensis and Candida parapsolosis . The MIC values of the Rhizoma Coptidis against C. glabrata , C. krusei and C. tropicalis were 50, 50 and 100 μg ml −1 respectively . We report here, for the first time, the potent antifungal activity of Rhizoma Coptidis and Cortex phellodendri Chinesis on three different non‐ albicans Candida species, C. glabrata , C. krusei and C. tropicalis and hence their possible use as therapeutic agents.