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Rhinocerebral zygomycosis in a young girl undergoing allogeneic stem cell transplantation for severe aplastic anaemia
Author(s) -
Sörensen Jan,
Becker Martina,
Porto Luciana,
Lambrecht Evelyn,
Schuster Tobias,
Beske Florian,
Rickerts Volker,
Klingebiel Thomas,
Lehrnbecher Thomas
Publication year - 2006
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2006.01300.x
Subject(s) - posaconazole , zygomycosis , medicine , neutropenia , girl , hematopoietic stem cell transplantation , surgery , transplantation , amphotericin b , mycosis , antifungal , dermatology , chemotherapy , biology , genetics
Summary We report on a 10‐year‐old girl with severe aplastic anaemia who developed rhinocerebral infection caused by Absidia corymbifera and a possible co‐infection caused by Alternaria alternata . Despite prolonged neutropenia, therapy with liposomal amphotericin B and posaconazole improved the clinical condition. Subsequently, the girl underwent allogeneic haematopoietic stem cell transplantation (HSCT) for the underlying disease, but the fungal infection remained under control with the antifungal treatment. No severe side effect of the antifungal drugs was noted. Unfortunately, the girl died 5 months after HSCT due to disseminated adenovirus infection.