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In vitro susceptibility of 15 strains of zygomycetes to nine antifungal agents as determined by the NCCLS M38‐A microdilution method
Author(s) -
Singh Jagpal,
Rimek Dagmar,
Kappe Reinhard
Publication year - 2005
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2005.01132.x
Subject(s) - rhizopus , rhizopus oryzae , microbiology and biotechnology , broth microdilution , caspofungin , mucor circinelloides , biology , amphotericin b , mucor , nystatin , minimum inhibitory concentration , mucorales , itraconazole , antifungal , aspergillus , food science , medicine , mucormycosis , antimicrobial , fermentation , pathology
Summary The in vitro susceptibility of 15 strains of six genera of zygomycetes including Rhizopus oryzae ( Rhizopus arrhizus ), Rhizopus stolonifer , Mucor circinelloides (three), Absidia corymbifera (three), Rhizomucor pusillus (three), Cunninghamella bertholletiae (two), and Syncephalastrum racemosum (two) to nine antifungal agents were determined by the NCCLS M38‐A broth microdilution method. Geometric means of the minimal inhibitory concentrations (MIC) were: amphotericin B 0.07 mg l −1 (range 0.03–0.5 mg l −1 ), nystatin 0.83 mg l −1 (range 0.25–4 mg l −1 ), itraconazole 0.59 mg l −1 (range 0.03 to >8 mg l −1 ), voriconazole 6.50 mg l −1 (range 2 to >8 mg l −1 ), ciclopiroxolamine 1.59 mg l −1 (range 0.5–4 mg l −1 ), and amorolfine 9.19 mg l −1 (range 1 to >16 mg l −1 ). All strains were resistant to 5‐flucytosine, fluconazole (MIC >64 mg l −1 ) and caspofungin (MIC >16 mg l −1 ).