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Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay
Author(s) -
Koc A. N.,
Silici S.,
Ayangil D.,
Ferahbaş A.,
Çankaya S.
Publication year - 2005
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2005.01128.x
Subject(s) - propolis , terbinafine , trichophyton rubrum , broth microdilution , trichophyton , antifungal , itraconazole , fluconazole , traditional medicine , microbiology and biotechnology , ketoconazole , minimum inhibitory concentration , pharmacology , biology , chemistry , medicine , antibiotics
Summary The in vitro activities of propolis against 29 strains of dermatophytes were compared with those of terbinafine, itraconazole, ketoconazole, and fluconazole. Minimal inhibitory concentrations (MICs) were determined according to a National Committee for Clinical Laboratory Standards broth microdilution method. Among the systemic antifungals tested, terbinafine was the most potent. Propolis showed important antifungal activity and it merits further investigation as a potentially useful agent for the treatment of dermatophytosis.