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In vitro activity of terbinafine and itraconazole against Aspergillus species isolated from otomycosis
Author(s) -
Karaarslan A.,
Arikan S.,
Ozcan M.,
Ozcan K. M.
Publication year - 2004
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2004.00988.x
Subject(s) - terbinafine , itraconazole , aspergillus terreus , minimum inhibitory concentration , broth microdilution , microbiology and biotechnology , aspergillus flavus , aspergillus niger , aspergillus , in vitro , biology , chemistry , pharmacology , antifungal , food science , antimicrobial , biochemistry
Summary The minimum inhibitory concentrations (MIC, μ g ml −1 ) of itraconazole and terbinafine against overall 34 Aspergillus isolates from the external ear canals with otomycosis have been determined with M38‐P microdilution method suggested by National Committee for Clinical Laboratory Standards (NCCLS). MIC intervals in 48 h determined by taking MIC‐2 value of itraconazole (the lowest drug concentration causing 50% inhibition of visible fungal growth) and MIC‐0 value of terbinafine (the lowest drug concentration causing 100% inhibition of visible fungal growth) as a basis have been found as follows: 0.125–1 and 0.06–0.5 μ g ml −1 for A. niger (22 strains), 0.06–0.25 and 0.06–0.125 μ g ml −1 for A. flavus (10 strains), 0.125 and 0.125–0.5 μ g ml −1 for A. terreus (two strains). It has been observed that both of the antifungal agents showed an in vitro activity against all Aspergillus species tested.