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Central nervous system infection due to Penicillium chrysogenum
Author(s) -
Kantarcıoğlu A. S.,
Apaydın H.,
Yücel A.,
De Hoog G. S.,
Samson R. A.,
Vural M.,
Özekmekçi S.
Publication year - 2004
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.2004.00974.x
Subject(s) - penicillium chrysogenum , itraconazole , terbinafine , amphotericin b , fluconazole , flucytosine , antifungal , microbiology and biotechnology , cerebrospinal fluid , penicillium , biology , medicine , pharmacology , food science
Summary Penicillium chrysogenum was isolated from three subsequent cerebrospinal fluid (CSF) specimens of a 73‐year‐old male patient without immunological compromise. The isolated was tested against five antifungal agents according to the NCCLS M38‐P macrodilution method. MICs were determined as follows: amphotericin B (AMB), 2 μ g ml −1 ; fluconazole (FLZ), 8 μ g ml −1 ; itraconazole (ITZ), 1 μ g ml −1 ; flucytosine (5FC), 0.125 μ g ml −1 ; and terbinafine (TRB), 0.06 μ g ml −1 . The patient has been cured with FLZ.