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Candida albicans suppresses transcription of melanogenesis enzymes in cultured melanocytes
Author(s) -
Kippenberger S.,
Bernd A.,
Menzel Ingrid,
Loitsch S.,
RamirezBosca Ana,
Kaufmann R.
Publication year - 1997
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.1997.tb00253.x
Subject(s) - candida albicans , reverse transcription polymerase chain reaction , enzyme , reverse transcriptase , transcription (linguistics) , biology , microbiology and biotechnology , polymerase chain reaction , human skin , gene expression , gene , biochemistry , genetics , linguistics , philosophy
Summary. Human skin can be colonized by different yeasts that may have an impact on skin pigmentation. In order to study this effect normal human melanocytes were cultured with different yeasts. Reverse transcription polymerase chain reaction (RT‐PCR) analysis gives evidence that Candida albicans suppresses the transcription of melanogenesis enzymes. Zusammenfassung. Das humane Integument kann von diversen Hefespezies besiedelt werden, dic einen Einfluss auf die Pigmentation haben können. Um diescn Effekt zu untersuchen, wurden normale humane Melanozyten mit verschiedenen Hefespezies kokultiviert. Durch RT‐PCR‐Analysen konnte gezeigt werden, dass Candida albicans die Transkription von Melanogenese‐Enzymen unterdrückt.