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The formation of hyphae of Candida albicans induced by cyclodextrins
Author(s) -
FeketeForgács Katalin,
Szabó Erika,
Lenkey B.
Publication year - 1997
Publication title -
mycoses
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.13
H-Index - 69
eISSN - 1439-0507
pISSN - 0933-7407
DOI - 10.1111/j.1439-0507.1997.tb00183.x
Subject(s) - candida albicans , hypha , yeast , corpus albicans , chemistry , microbiology and biotechnology , mycelium , cyclodextrin , biology , biochemistry , botany
Summary. Hyphal growth of Candida albicans was observed when yeast was cultured at 27 d̀C in liquid media containing 1% Tripcasine® and 1.8% cyclodextrins (α, β, and γ respectively). Tripcasine as the sole nitrogen source did not induce the formation of hyphae of C. albicans , but cyclodextrins, especially CD‐β, were able to induce yeast‐mycelial transition. In the TCD‐β media 25–30% septate hyphae form was observed. This study indicates the existance of an uptake system for CDs in C. albicans , provided these compounds are linearised in the medium. The CDs are inducers of hyphae and they may enter the C. albicans cells as linear oligosaccharids. Zusammenfassung. Hyphenwachstum von Candida albicans wurde beobachtet, wenn die Hefe im Nährmedium mit 1% Tripcasin® und 1,8% Cyclodexrin (jeweils in α‐, β‐ oder γ‐Form) gezüchtet wurde. Tripcasin als alleinige Stickstoffquelle führte zu keinem Hyphenwachstum, Cyclodextrine jedoch — insbesondere das β‐Cyclodextrin — sind befähigt, die Umwandlung der Hefe in Myzelien herbeizuführen. 25–30% der Hefezellen wurden in β‐cyclodextrinhaltiger Nähriösung zu Hyphen umgewandelt. Die Studie zeigt, daß C. albicans die Cyclodextrine aufnehmen kann, wenn diese Moleküle im Nährmedium in linearer Form vorliegen. Cyclodextrine stellen somit Induktoren der Hyphenform von Candida ‐ Zellen dar.

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