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Inhibition of Plant Viruses by Human Gamma Interferon
Author(s) -
Vicente M.,
Fazio G.,
Menezes M. E.,
Golgher R. R.
Publication year - 1987
Publication title -
journal of phytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 60
eISSN - 1439-0434
pISSN - 0931-1785
DOI - 10.1111/j.1439-0434.1987.tb04380.x
Subject(s) - datura stramonium , biology , tobacco mosaic virus , inoculation , virology , interferon , monoclonal antibody , inhibitory postsynaptic potential , virus , serial dilution , plant virus , incubation , microbiology and biotechnology , botany , horticulture , antibody , immunology , biochemistry , medicine , alternative medicine , pathology , neuroscience
In order to evaluate the inhibitory effect induced by gamma interferon (Hu g IFN) on plant viruses, pre‐inoculation treatments (brushing the leaves) were carried out in two different plant‐virus systems: D. stramonium * TMV and G. globosa * PVX. Results showed that Hu g IFN induced a higher inhibitory effect (IP = 90%) in D. stramonium * TMV system (Table 1). Comparing the antiviral effect of the three IFNs: gamma, alpha and beta‐like interferons, it was verified that Hu g IFN was more effective than the other two (Table 2). Hu g IFN was also used for post‐inoculation treatments (incubation of tobacco leaf‐discs) and using different dilutions a dose response curve could be obtained (Fig. 1). Hu g IFN inhibitory effect was confirmed by the neutralization of its inhibitory effect using monoclonal antibody (Table 3). Results suggest that although the three IFNs differ in their composition, they present similarities in their biological activities probably triggering an antiviral state in plants.