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Antiphytovirale Verbindungen mit nichtzyklischer Azin Struktur
Author(s) -
Schuster G.,
Heinisch L,
Schulze W.,
Ulbright H.,
Willitzer H
Publication year - 1984
Publication title -
journal of phytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 60
eISSN - 1439-0434
pISSN - 0931-1785
DOI - 10.1111/j.1439-0434.1984.tb00483.x
Subject(s) - azine , tobacco mosaic virus , potato virus x , biology , quinoline , psoralen , horticulture , plant virus , virus , nuclear chemistry , chemistry , medicinal chemistry , organic chemistry , virology , biochemistry , dna
Antiphytoviral compounds with noncyclic azine structutre The antiphytoviral activities of variously substituted compounds with noncylic azine structures have been studied f a total of 90 tested compunds 42 had the effect of more or less strong inhibiting the concentration of potato virus X (PVX) in inoculated and / or secondarily infected leaves of Nicotiana tabacum L. cv Samsun (Table.1) An effect on the virion of PVX in vitro couldn't be observed (Table.2) Thus the substances may interact with the virus replication. Some of them also reduced the number of local lesions caused by tabacco mosaic virus on leaves of Nicotiana glutinosa L. (Table‐3) Several Compounds proved exellent synergists of 2,4‐ dioxohexahydro‐ 1,3,5‐ triazine (DHT = 5 azadihydrouracil; Table 4) Pyridine‐ 3‐ aldehyde S ethyl isothiosemicarbazone and the Cu complex of 1‐ ethyl‐isatine S‐ ethyl isothisosemicarbazone when used in combination with 2,4 dioxohexahydro‐ 1,3,5, triazine, greatly increased the mass of potato tubers produced from plantlets grown up from patato eye cutting as compared with the indentical control Simultaneously the mentioned substances reduced the number of symptom bearing eye cutting plants Quinoline 2‐ aldehyde‐ N‐ oxide S‐ allyl‐isothiosemicarbazone had the effect of very greatly reducing the number of symptom‐bearing plants without substantially influencing the mass of tubers (Table 5). Thus some compounds with noncyclic azine structure especially when used in combinitation with DHT, may be of high interest for practical application Comparing the structures of compounds with noncyclic azine structure active against plant or human viruses it should be noted that antiphytoviral compounds active in these two different virus host systems often are closely related structurally.