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Absorption, tissue distribution, metabolism and excretion of ormetoprim and sulphadimethoxine in cod ( Gadus morhua ) after oral administration of Romet 30
Author(s) -
Samuelsen O. B.
Publication year - 2006
Publication title -
journal of applied ichthyology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.392
H-Index - 62
eISSN - 1439-0426
pISSN - 0175-8659
DOI - 10.1111/j.1439-0426.2006.00703.x
Subject(s) - gadus , atlantic cod , excretion , biology , cmax , metabolism , absorption (acoustics) , endocrinology , oral administration , medicine , pharmacokinetics , distribution (mathematics) , pharmacology , plasma concentration , fish <actinopterygii> , fishery , mathematical analysis , mathematics , physics , acoustics
Summary Uptake, tissue distribution, metabolism and elimination of sulphadimethoxine (SDM) and ormetoprim (OMP) were examined in Atlantic cod ( Gadus morhua ) following oral administration of Romet 30 at a dose of 5 mg OMP and 25 mg SDM per kilogram fish. Absorption and elimination was rapid for OMP and slow for SDM characterized by peak plasma concentrations ( C max ) of 1.44 and 20.93 μ g ml −1 after 7 and 59 h, respectively, and plasma elimination halflives ( t 1/2 β ) of 7 h for OMP and 56 h for SDM. High concentrations of SDM were found in the bile indicating high biliary excretion of this drug whereas moderate concentrations of N ‐acetylated SDM were found in tissues and bile indicating N ‐acetylation to be a less important metabolic pathway for SDM in cod. The biliary concentration of OMP was low.