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Pharmacokinetics of cephalexin in sea bream, Sparus aurata (L.), after a single intraperitoneal injection
Author(s) -
Katharios P.,
IliopoulouGeorgudaki J.,
Antimisiaris S.,
Verri T.,
Toma P.,
Acierno R.,
Maffia M.
Publication year - 2004
Publication title -
journal of applied ichthyology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.392
H-Index - 62
eISSN - 1439-0426
pISSN - 0175-8659
DOI - 10.1111/j.1439-0426.2004.00578.x
Subject(s) - pharmacokinetics , biology , intraperitoneal injection , compartment (ship) , body weight , area under the curve , sparidae , zoology , plasma concentration , pharmacology , fish <actinopterygii> , fishery , endocrinology , oceanography , geology
Summary The pharmacokinetic properties of cephalexin were studied in sea bream (mean weight 77 g), Sparus aurata (L.) after a single intraperitoneal injection (200 mg kg −1 ). Pharmacokinetic analysis of the serum concentrations vs time points obtained was performed using non‐compartmental analysis and a compartmental pharmacokinetic model approach. In the latter case, a two‐compartment open model with a lag time gave the best fitting. The maximum peak serum concentration was 5.018 mg ml −1 kg −1 1 h post‐treatment. The area under the curve ( AUC ) cephalexin was 17.394 mg·h kg −1 and the elimination half‐life of 1.83 h.