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Effect of sample size and number of doses for the determination of LD50
Author(s) -
Moermans R.,
Hecke P.
Publication year - 1995
Publication title -
journal of applied entomology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 60
eISSN - 1439-0418
pISSN - 0931-2048
DOI - 10.1111/j.1439-0418.1995.tb01350.x
Subject(s) - biology , toxicology , statistics , sample size determination , log normal distribution , value (mathematics) , mathematics
The effects of the LD50 value of the number of applied doses and the number of individuals submitted to each dose were studied. Simulated data were used and the lognormal distribution was assumed. Increasing the number of individuals submitted to the doses results in a much larger effect than increasing the number of doses. To obtain an accuracy of 50% of the true value, with a chance of .85 that this should happen, at least 20 individuals per dose should be used.