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Evaluation of dietary stevioside supplementation on anti‐human serum albumin immunoglobulin G, Alpha‐1‐glycoprotein, body weight and thyroid hormones in broiler chickens
Author(s) -
Daneshyar M.,
Geuns J. M. C.,
Willemsen H.,
Ansari Z.,
Darras V. M.,
Buyse J. G.,
Everaert N.
Publication year - 2012
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1111/j.1439-0396.2011.01188.x
Subject(s) - stevioside , broiler , medicine , endocrinology , albumin , antibody , saline , orosomucoid , thyroid , biology , zoology , chemistry , glycoprotein , immunology , biochemistry , alternative medicine , pathology
Summary Sixty male broiler chickens fed a diet supplemented with 130 mg/kg stevioside (S group) or an unsupplemented diet (C group) from day 1 of age onwards. On day 21 of age, ten birds from either the S (SH) or C (CH) group were injected subcutaneously with 100 μ g human serum albumin (HSA) and ten others from either S (SP) or C (CP) group injected with 100 μ l phosphate‐buffered saline (PBS) in the same way. There were no significant effect of supplementation nor interaction with age on average body weights, T 3 and T 4 concentrations of non‐injected chickens. After the primary immunization, α 1 ‐glycoprotein concentrations increased in all treatment groups except the CP group, and were significantly higher in the CH group in relation to the other groups. Fourteen and 18 days after the primary immunization, HSA injected chickens of both dietary treatments had significantly higher anti‐HSA immunoglobulin G (IgG) levels than their PBS injected controls. No effect of stevioside supplementation was observed for IgG level. In conclusion, dietary stevioside inclusion can attenuate the pro‐inflammatory response after stimulation of the innate immune response in broiler chickens.