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Effects of dietary energy intake and cold exposure on kinetics of plasma glucose metabolism in sheep
Author(s) -
Sano H.,
Sawada H.,
Takenami A.,
Oda S.,
AlMamun M.
Publication year - 2007
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1111/j.1439-0396.2006.00634.x
Subject(s) - energy metabolism , metabolism , plasma glucose , kinetics , chemistry , carbohydrate metabolism , zoology , food science , endocrinology , biology , biochemistry , diabetes mellitus , physics , quantum mechanics
Summary An isotope dilution method using [U‐ 13 C]glucose injection was applied to determine the effects of dietary energy intake and cold exposure on plasma glucose metabolism in sheep. The sheep were assigned to two dietary treatments and were fed on diets containing either 100% or 160% of ME and both containing 150% of dietary crude protein intake for maintenance. The sheep were exposed from a thermoneutral environment (23°C) to a cold environment (2–4°C) for 5 days. The isotope dilution method was performed on the 18th day in the thermoneutral environment and on the fifth day of cold exposure. Plasma concentrations of glucose and NEFA increased (p < 0.05) during cold exposure for both diets. Plasma glucose pool size remained unchanged (p = 0.67), but plasma glucose turnover rate tended to increase (p = 0.07) with increased energy intake. Both pool size and turnover rate of plasma glucose increased (p = 0.01 and p = 0.0001, respectively) during cold exposure. No significant diet × environment interaction was detected. It is concluded that plasma glucose metabolism was influenced by both dietary energy intake and cold exposure, and plasma glucose metabolism in response to cold exposure was not modified by energy intake in sheep under the conditions (2–4°C on the fifth day) of the present experiment.