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Lipoic acid is 10 times more toxic in cats than reported in humans, dogs or rats
Author(s) -
Hill A. S.,
Werner J. A.,
Rogers Q. R.,
O'Neill S. L.,
Christopher M. M.
Publication year - 2004
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1111/j.1439-0396.2003.00472.x
Subject(s) - cats , toxicity , lipoic acid , antioxidant , chemistry , pharmacology , acute toxicity , medicine , biochemistry
Summary The antioxidant lipoic acid (LA) is administered to humans and pets. We described acute toxicity and maximum tolerated dose (MTD) of LA in cats. In progression, 10 healthy adult male cats received orally 60 (high), 30 (low), or 0 mg LA/kg (control). Serum enzyme activities and concentrations of bile acids, ammonia, amino acids (AA), LA and dihydrolipoic acid (DHLA) were measured, and tissues examined microscopically. Significant clinical toxicity with changes in ammonia and AA concentrations occurred in all high‐dose cats. Oral LA produced hepatocellular toxicity and MTD was <30 mg/kg in cats.