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Effects of L‐carnitine administration on treadmill test performance of untrained dogs
Author(s) -
Iben CH.
Publication year - 1999
Publication title -
journal of animal physiology and animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.651
H-Index - 56
eISSN - 1439-0396
pISSN - 0931-2439
DOI - 10.1111/j.1439-0396.1999.00224.x
Subject(s) - carnitine , coenzyme a , acetyl coa , acyl coa , treadmill , chemistry , medicine , endocrinology , biochemistry , metabolism , biology , enzyme , reductase
Carnitine (trimethyl‐γ‐amino‐β‐hydroxybutyrate; molecular weight 161 g) is not only essential for the transport and utilization of long‐chain fatty acids, it also occurs as a medium and short‐chain ester and serves as an acetyl and acyl pool. Short‐term muscle exercise causes an increase of acetyl‐carnitine levels in the serum and in the liver. It prevents the accumulation of acyl‐coenzyme A (CoA) and provides the organism with CoA by producing acetyl‐carnitine from acetyl‐CoA. Human muscle tissue contains approximately 10 μmol CoA/kg, whereas carnitine levels range between 2000 and 5000 μmol/kg.