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Role of selection and inbreeding on the incidence of cutaneous malignant melanoma in Sinclair swine
Author(s) -
GomezRaya L.,
Amoss M.S.,
Da Y.,
Beattie C.W.,
Ash O.,
Rauw W.M.
Publication year - 2009
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/j.1439-0388.2008.00779.x
Subject(s) - inbreeding , selection (genetic algorithm) , incidence (geometry) , biology , melanoma , genetics , zoology , evolutionary biology , medicine , environmental health , mathematics , computer science , population , artificial intelligence , geometry
Summary This paper reports the quantitative analysis of the historical database of a herd of Sinclair swine affected by cutaneous malignant melanoma. The herd was under partial and non‐systematic selection for melanoma susceptibility (animals having at least one tumour during the first 6 weeks of life). Weighted selection differentials for the number of tumours at birth and the number of tumours at 6 weeks were generally positive and between −0.43 and 4.76 tumours for the number of tumours at 6 weeks. Estimates of the heritability for number of tumours at birth and at 6 weeks using 1934 animals were 0.27 (±0.03) and 0.25 (±0.03), respectively. The estimate of the genetic correlation between these two traits was 0.95 (±0.03). Genetic trends were positive for the number of tumours at birth and at 6 weeks. In spite of positive selection differentials and a moderate heritability, there was a negative phenotypic trend in the number of tumours. Natural selection might be acting in a direction opposite to artificial selection in the Sinclair herd. The slopes of the regression of the number of tumours at birth, at 6 weeks, and melanoma susceptibility on individual inbreeding coefficients were non‐significant, indicating no evidence of dominance. The number of live‐born pigs was lower in litters from parents susceptible to the disease (p < 0.01).