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Association analysis of the constructed linkage maps covering TLR2 and TLR4 with clinical mastitis in Norwegian Red cattle
Author(s) -
Opsal M.A.,
Lien S.,
BrennaHansen S.,
Olsen H.G.,
Våge D.I.
Publication year - 2008
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/j.1439-0388.2007.00704.x
Subject(s) - biology , genetics , mastitis , linkage disequilibrium , single nucleotide polymorphism , genetic association , gene , candidate gene , association mapping , genetic linkage , population , tlr2 , immune system , tlr4 , genotype , microbiology and biotechnology , medicine , environmental health
Summary Toll‐like receptors (TLR) are important cell‐surface molecules mediating immune responses. Previous studies have identified TLR2 and TLR4 as potential candidate genes for disease resistance. In this study, dense linkage maps comprising single nucleotide polymorphisms (SNPs) have been constructed for the chromosomal regions harbouring TLR2 and TLR4 on bovine chromosome 17 and 8. The most likely marker orders for both regions were compared with the corresponding human map positions and used to reorder bovine scaffolds available from the bovine genome sequence assembly (Btau_3.1). A combined linkage and linkage disequilibrium method was used to investigate possible associations between the TLR genes and mastitis susceptibility recorded in the Norwegian Red cattle population. The analysis did not detect any significant association between the chromosomal regions surrounding TLR2 and TLR4 and mastitis in Norwegian Red cattle.