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Novel variants within the coding regions of the Slc11A1 gene identified in Bos taurus and Bos indicus breeds
Author(s) -
Martínez R.,
Dunner S.,
Barrera G.,
Cañon J.
Publication year - 2008
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/j.1439-0388.2007.00690.x
Subject(s) - genetics , gene , biology , coding region , allele , genotype , missense mutation , brucellosis , single nucleotide polymorphism , intron , polymorphism (computer science) , mutation , virology
Summary Although in the cow the genetic resistance to brucellosis has been previously attributed to the Slc11A1 gene encoding Nramp1 protein, none of the mutations described to date seems to be the cause. To be able to associate another polymorphism of the gene to brucellosis resistance, we characterized the gene and identified in different breeds of Bos taurus and Bos indicus , six new variants among a total of 11 single nucleotide mutations, of which five occurred in the coding sequence (three are missense mutations), one in the promoter region and five in introns. The allelic and genotypic frequencies calculated revealed differences (p < 0.05) among the breeds studied.