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Study on the association of BoLA‐DRB3.2 alleles with clinical mastitis in Norwegian Red cows
Author(s) -
Kulberg S.,
Heringstad B.,
Guttersrud O.A.,
Olsaker I.
Publication year - 2007
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/j.1439-0388.2007.00662.x
Subject(s) - mastitis , allele , genotyping , biology , haplotype , genetics , genotype , allele frequency , immunology , gene , microbiology and biotechnology
Summary Genotyping of bovine leucocyte antigen DRB3.2 ( BoLA‐DRB3.2 ) in a total of 523 Norwegian Red (NR) cows from two groups selected for high protein yield and low clinical mastitis, respectively, identified 27 previously reported BoLA‐DRB3.2 alleles across the groups. Significant differences in BoLA‐DRB3.2 allele frequencies were found between the selection groups. Alleles *13 , *18 , *22 and *27 had a significantly higher frequency in cows selected for low clinical mastitis, while alleles *3 , *9 , *11 and *26 had a higher frequency in cows selected for high protein yield. Associations between BoLA‐DRB3.2 alleles and clinical mastitis were analysed based on mastitis data from 741 072 first‐lactation NR cows, of which 452 were genotyped. Alleles *22 and *26 were found to be associated with increased clinical mastitis, while alleles *7 , *11 , *18 and *24 had a favourable effect on mastitis resistance. Contradictory results from different studies investigating associations between BoLA‐DRB3.2 alleles and mastitis indicate that future studies should focus on associations of mastitis with BoLA haplotypes rather than with single BoLA genes.