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Haplotype analysis of β ‐actin gene for its association with sperm quality and boar fertility
Author(s) -
Lin C.L.,
Jennen D.G.J.,
Ponsuksili S.,
Tholen E.,
Tesfaye D.,
Schellander K.,
Wimmers K.
Publication year - 2006
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/j.1439-0388.2006.00622.x
Subject(s) - sperm , biology , fertility , semen quality , semen , sperm motility , haplotype , andrology , genetics , population , candidate gene , semen analysis , boar , male fertility , sperm quality , gene , genotype , infertility , pregnancy , medicine , environmental health
Summary β ‐actin ( ACTB ) was examined as a direct functional candidate gene for the possible association with sperm concentration, motility (MOT), semen volume per ejaculate, plasma droplet rate, abnormal sperm rate (ASR) and the fertility traits, non‐return rate and number of piglets born alive (NBA). Three polymorphisms in intron 3 (T>C) and one polymorphism in exon 4 (T>C) of porcine ACTB gene were identified by comparative sequencing of animals of the breeds Pietrain and Hampshire. Association analysis revealed that haplotypes affected the variation of the traits MOT, ASR and NBA. The beneficial haplotypes may provide considerable improvement of sperm quality and fertility in the tested commercial boar population.