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Isolation and characterization of the canine NKX2‐5 gene
Author(s) -
Hyun C.,
Lavulo L.,
O'Leary C.,
Kim JT.
Publication year - 2006
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/j.1439-0388.2006.00584.x
Subject(s) - gene , biology , homology (biology) , isolation (microbiology) , morphogenesis , genetics , heart development , computational biology , bioinformatics , embryonic stem cell
Summary We report the first isolation and characterization of the canine NKX2‐5 gene. This canine homologue has high homology in genomic structure and functional domains to other NKX2‐5 across a number of different species. Given the critical role of NKX2‐5 in cardiac morphogenesis as seen in human and mouse studies of congenital heart defects, the availability of the canine NKX2‐5 provides a good starting point for identifying mutations that may be responsible for certain forms of canine congenital heart defects.