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New SNPs in the IGF2 gene and association between this gene and backfat thickness and lean meat content in Large White pigs
Author(s) -
Vykoukalová Z.,
Knoll A.,
Dvořák J.,
Čepica S.
Publication year - 2006
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/j.1439-0388.2006.00580.x
Subject(s) - biology , single nucleotide polymorphism , linkage disequilibrium , genetics , locus (genetics) , genotyping , quantitative trait locus , gene , intron , population , genotype , demography , sociology
Summary IGF2 ‐in3‐G3072A is a causative mutation for paternally expressed quantitative trait loci on the p arm of porcine chromosome 2 with substantial effect on muscle growth and backfat thickness. The linkage disequilibrium between IGF2 ‐in3‐G3072A and IGF2 ‐in7‐G162C ( IGF2‐Nci I) in four breeds and associations between these polymorphisms and growth and meat performance in pigs of the Large White breed were analysed. A significant effect of these polymorphisms on backfat thickness and lean meat content was found. In addition, we identified two new single nucleotide polymorphisms (SNPs) in intron 7 of the gene. The existence of complete linkage disequilibrium between IGF2 ‐in3‐G3072A locus in the population under study where the locus segregated and SNPs in intron 7 of the IGF2 gene detectable with simple and reliable polymerase chain reaction–restriction fragment length polymorphism techniques ( G162C , C179G and G186T ) offer possibilities to use these SNPs for genotyping of quantitative trait nucleotide in Large White and Landrace breeds.