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Relationship between inbreeding and sex‐hormone concentration in rats under stress. II. The influence of various inbreeding levels on steroid‐sex‐hormone concentrations in two types of stress
Author(s) -
Kosowska B.,
Zdrojewicz Z.
Publication year - 1996
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/j.1439-0388.1996.tb00598.x
Subject(s) - inbreeding , medicine , testosterone (patch) , endocrinology , hormone , steroid , inbred strain , biology , steroid hormone , population , genetics , gene , environmental health
Summary The effect of inbreeding, stress, and genetic line on serum levels of steroid sex hormones (progesterone, 17β‐oestradiol, testosterone) was studied in rats. The effects of different inbreeding level (0% inbred — control groups; 50% and 91% inbred — experimental groups) on steroid‐sex‐hormone serum concentration were studied in two lines and in their cross: 1. Wistar albino Ipf:RIZ outbred rats (B); 2. Wild Norway rats (D); and 3. The hybrids between rats of lines 1 and 2 (B × D). Both males and females were exposed to ether anaesthesia (subcontrol groups), and physical stress (subexperimental groups) involving 24 h starvation followed by 3 h swimming. A significant relationship was found between the inbreeding coefficient of an animal and all steroid‐sex‐hormone concentrations examined. Concentrations of all hormones decreased significantly with increasing homozygosity: 17β‐oestradiol in line B, progesterone in lines D and D × B, and testosterone in lines B and B × D decreased in a linear manner, while 17β‐oestradiol in lines D and B × D and testosterone in line D followed a quadratic function. The harmful effect of physical stress on 17β‐oestradiol and testosterone concentration was significant (p < 0.01) in all lines. Double interactions between the inbreeding level and stress in lines D and D × B were found to be significant (p < 0.01), and to affect 17β‐oestradiol and testosterone concentrations. Zusammenfassung II. Einfluß von Inzucht auf Steroidgeschlechtshormone unter zweierlei Streß Die Wirkung von Inzucht (0, 50, 91%), Streß und Genotyp auf Serumspiegel der Steroid‐geschlechtshormone Progesteron, 17β‐Östradiol und Testosteron wurde in drei Rattenherkünften: 1. Wistar Albino IpF: RIZ Auszucht (B); 2. Wilde Ratten (D); 3. Ihren Kreuzungen (B × D) untersucht. Männliche und weibliche Tiere verschiedener Inzuchtgrade wurden Äther Anästhesie (Subkontrolle) und physischem Streß (Subexperimentelle Gruppe) in Form von 3 Stunden Schwimmen nach 24 Stunden Futterentzug ausgesetzt. Zwischen Inzuchtgrad und Serumhormonspiegel zeigten sich signifikante Beziehungen. Hormon Konzentrationen nahmen mit steigender Inzucht signifikant ab: 17‐β‐Östradiol in B, Progesteron in D und D × B und Testosteron in B und B × D in linearer Weise, 17‐β‐Ostradiol in D und B × D und Testosteron in D folgten einer quadratischen Funktion. Physischer Streß war in allen Gruppen hinsichtlich 17‐β‐Östradiol und Testosteron schädlich. Doppelte Interaktion war zwischen Inzucht und Streß bei D und B × D signifikant und beeinflußte 17‐β‐Östradiol und Testosteron Konzentrationen.