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High levels of cathepsins B , L and S in human seminal plasma and their association with prostasomes
Author(s) -
Inayat S.,
Larsson A.,
Ronquist G. K.,
Ronquist G.,
Egberg N.,
Eliasson R.,
Carlsson L.
Publication year - 2012
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2012.01299.x
Subject(s) - cathepsin , semen , andrology , cathepsin l , cathepsin b , cathepsin d , chemistry , medicine , endocrinology , biology , enzyme , biochemistry
Summary Semen is a heterogenous and complex fluid with different functions, some of them well known, others still obscure. The aim of this study was to investigate the presence of cathepsins B , S and L in human seminal plasma and their possible associations with other semen variables. Cathepsin B , L and S concentrations were measured in seminal plasma from 99 men utilising commercial ELISA kits. Seminal plasma cathepsin B was approximately 70 times higher, while the cathepsin L values were approximately 500 times higher and the cathepsin S values approximately 40 times higher in seminal plasma than in a group of serum samples. The study shows that seminal plasma contains high levels of cathepsins B , L and S . All three cathepsins were also bound to the surface of prostasomes.