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Evaluation of male‐mediated reproductive toxic effects of methamidophos in the mouse
Author(s) -
Farag A. T.,
Radwan A. H.,
Eweidah M. H.,
ElMazoudy R. H.,
ElSebae Abd ElKhaliek
Publication year - 2012
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2010.01113.x
Subject(s) - methamidophos , epididymis , sperm , sperm motility , biology , toxicity , andrology , resorption , physiology , reproductive toxicity , reproduction , medicine , endocrinology , pesticide , ecology , agronomy
Summary The reproductive toxicity of the insecticide methamidophos was studied in male mice. Adult male mice were treated by gavage with methamidophos at doses of 0, 1, 2 and 3 mg kg −1 day −1 for 4 weeks before mating with untreated females. Brain and skeletal muscle acetylcholinesterase activity was inhibited in the middle‐ and high‐treated groups. Methamidophos treatment was associated with a decreased number of live foetuses and an increased number of dead and resorption foetuses at 2 and 3 mg kg −1 day −1 treated groups. The per cent morphologically normal spermatozoa were affected in the 2 and 3 mg kg −1 day −1 dose groups; however, sperm motility and count were decreased in the same treated groups compared to the control. Histological examination of brain, muscles, testes and epididymis revealed histological abnormalities in a dose‐dependent manner. The current study demonstrated adverse effects of male methamidophos exposure on pregnancy outcome with effects on sperm parameters at 2 and 3 mg kg −1 day −1 .