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Glutathione S‐transferase M1 and T1 polymorphisms in Turkish patients with varicocele
Author(s) -
Acar H.,
Kılınç M.,
Guven S.,
Inan Z.
Publication year - 2012
Publication title -
andrologia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.633
H-Index - 59
eISSN - 1439-0272
pISSN - 0303-4569
DOI - 10.1111/j.1439-0272.2010.01103.x
Subject(s) - varicocele , oxidative stress , glutathione s transferase , glutathione , genotype , biology , medicine , glutathione transferase , andrology , endocrinology , gene , genetics , enzyme , biochemistry , infertility , pregnancy
Summary Several studies have shown that high oxidative stress levels are associated with varicocele. The GST (glutathione S‐transferase) family of genes is critical in the protection of cells from oxidative stress because they utilise as substrates a wide variety of products of oxidative stress. The objective of this study was to assess the relationship between genetic polymorphism in GST‐M1 and GST‐T1 and varicocele using 109 varicocele patients and 123 controls. Varicoceles were clinically graded as Grade 1, Grade 2 and Grade 3. GST‐M1 and GST‐T1 genes were determined by polymerase chain reaction. Although the GST‐M1 null genotype was higher in Grade 3 than in Grade 1, 2 and controls, there were no statistical differences between control group and varicocele groups according to GST‐M1 and GST‐T1 null genotype. Men with varicocele do not have more GST‐M1 and GST‐T1 null polymorphisms than men without varicocele. Additional studies are needed to assess the exact mechanism by which the varicocele corresponds to elevated ROS levels.